It isn't a reboot. It's set after Resident Evil 6 and ties into the story/world, but features an entirely new cast of characters.
New characters used to help with the horror. "One of the places we got to in the series until now is that you’re playing these superhero characters…to bring horror experience right to the player…can’t be seeing through a macho hero character"
Herbs return as your only source of health regen. Combining/mixing, etc.
Stronger, but fewer, enemies. "One thing I can say is it’s not going to be some kind of zombie horror where you have to mow down zombies"
Inventory system is a mix between traditional Resident Evil and Resi 4's Attache case.
It was first-person before VR. "If you want people to experience horror, and you want it in the most direct and visceral way possible, you know putting yourself in the position to see what the character sees is the best possible way to do that."
Resident Evil 1 REmake is the main inspiration.