To some extent I actually agree that I dislike Fem Ryder's appearance.
However, my issue with it has nothing to do with beauty or anything like that at all. My problem is that the in-game model doesn't actually match the real model.
Compare her to Mass Effect 1. Commander Shepard looks identical to the real-life model he was based on (Mark Vanderloo). However, Jayde Rossi (the real-life model that Fem Ryder was based on) looks nothing like her in-game model. I don't particularly mind if a game decides to create an original character design, but if you're going to use a model...I think you should do a good job replicating what they look like. I thought Commander Shepard was an accurate and faithful recreation of the real person in video game form, which made me see Shepard as more of a real person.
However, the game has far worse issues than just Fem Ryder's appearance.