I tend to think that if it becomes so massive to the point that it's a meme, it's understandable if spoilers happen. However, I'll point out that when Sarah played FFVII we managed to get her all the way through disk one to the point of her seeing the obvious event and being in utter disbelief. Tears were shed. It was all very emotional. So there is still a lot to be said for not spoiling things too bluntly all over the place.

How you gauge a massive spoiler becoming a meme? Urgh, I don't even know. Very subjective but that's life sometimes.