Venat is a person/godlike being who thinks on the extremely grand scale to the point of thinking nothing of sacrificing a Dalmasca or Nabradia or two in service of a higher purpose, and he incites Vayne and Cid to do the same. I don't think any of them, neither Venat nor the humans, are in denial of the pain and suffering they caused, but it's straight up not what really matters to them.

Probably the most interesting part to me though is that beyond this, Venat, Cid and Vayne are also shown to have a legitimate friendship. Everything we see between them seems to imply they do not use one another or think themselves higher than the other. They just genuinely respect and even value each other. The scene that stands out the most there is before the true final boss when Vayne proclaims himself a failure but Venat comforts him and walks alongside him during what they both likely knew were going to be Vayne's final moments. They stay true to their ambition still, but there's something really human in their relationship.