I don't know. Disney owns DP now but to what extent he'll play a role in future MCU properties is still up in the air.

But for fun, I came up with a potential exchange of dialogue between the two. I don't know if this belongs here or in writer's corner.

Loki sees Deadpool. "Oh, god."
"Ooh, Loki. Praying to yourself again, I see."
"What the hell are you doing here?"
"I came to see you, buddy. You're like Mary Poppins, y'know? You're my favorite person."
"How did you even get here?"
"Well, I was over there and then I walked over here."
"I don't mean 'here' here. I mean how did you... alright. Try to keep up with me on this."
"Sure thing."
"I'm an interdimensional traveler."
"Right."
"I've been hurtling through space, jumping from planet to planet..."
"Gotcha."
"In case you hadn't noticed, this is not Earth."
"I had noticed. This place is weird in all the right ways."
"...okay. Wade. How. Are. You..."
"I'm fine, thank you, that's sweet of you to ask."
"HERE! How are you here? Now! On this planet!"
"Are you alright? You seem upset."
"Just answer the question, Wade. How is it that you seem to pop up everywhere I go?"
"What can I say? I don't know, I guess I just find you incredibly attractive."
"You are simply ridiculous."
"No. I'm serious. Consider this: You and I are tight like that." Deadpool gestures. "We have an unbreakable bond and wherever you go, I will follow. Isn't that great?"
Loki considers this a moment and then sighs. "Wonderful."