Yeah. I did spent a chapter or two at some point with them off, but the only thing it changed in my actual experience is I spent more time looking at icons at the bottom right of my screen (because of auto-combo) and less time enjoying the cinematic experience that some fights have to offer. I was already still trying to do perfect dodges even with autododge on, so it was more of a backup than a primary.

In retrospect, I think the main reason I left them on, aside from what I mentioned above, is that all the other options felt extremely uninspired. I was always waiting for something that felt like it would be really interesting and I never really hit that point. 95% of the accessories are just "make it happen 5% more often" and in an action game that just never catches my interest.