Destruction humanity has caused? The ONLY destruction is mako reactors. They were a fairly recent thing, and were destroyed within a couple of decades. The company that made them was destroyed.

It sounds like cold-blooded murdering for me for Holy to wipe out humans on such a small chance.

When humans had the mako reactors, they posed a small threats. HUMANs fixed the problem. So now that the threat is ended, THEN Holy decides to destroy humanity? Why not just leave humans to fix human problems?

You still haven't explained one thing: How does Holy decide what's good and bad? What's your definition of "evil" that ALL humans meet, since you seem to think Holy killed every human being on the Planet.