BOU: I don't like that supernatural angle. I'll admit it can be creepy as hell, but I'm not expecting just find myself in some ghost town anytime soon. However, the idea of a few renegade scientists (or hell, even a few of Uncle Sam's or Adolf's or whoever's government boys) to be messing around with human genetics.

And that thing can be at least mildly chilling. Especially when you here how the people doing it describe it. They just don't seem to care.

I don't know if you've played Resi-CV:X, but there's a part of the game where you wander into a bunk house where prisoners were being kept. In there you find a diary belonging to a dead inmate that describes people being taken to a certain building and never returning. Later in the game you go to said building, and you find another diary, this one belonging to the guy who runs the building. It's about a doctor who thinks he's sort of possessed and tortures people for fun, and a need to. For me, the whole psycho-mutilation-happy doctor is much creepier than ghosts and that kind of thing because it's just more possible. I don't think I've explained this as well as I wanted to, but I think you get the point.