Wow this is awesome. I just discovered the graphics enhancements today with Zsnes. The game looks a lot better with these video settings:

1024x768 DS FULL
Triple Buffering
Super Eagle Engine

These sound options work good:

Stereo sound (Yes, mono is the default)
44100HZ Sampling Rate
Sound Buffering
8-point Interpolation (no I don't really notice a difference between interpolation options)
Hi-Quality Lowpass

If anyone knows of better settings, please post.