You could beat the game with relative ease not junctioning...even those annoying enemies.....but not for the whole game, just till you got ForbidMed Refine and could make all the STR, MAG, SPR, SPD, VIT, and HP ups you can....then use nothing but aura stones.....but like soulIce said...some bosses have insane hp and defense...wthout meltdown it'd be freaking annoying...unless u had the Loinheart limit.....and Pulse ammo..it could be done but it'd be a gruelingly hard job to get enough stat ups to make ur entire party or even a select 3 to their full potential.....