The Legend of Zelda: A Link To The Past. I played it from start to finish, not dieing a single time, so that I could have a death count of zero (it gives you a death count each time you save and quit, which annoyed me when I was 12). It took about ten hours I think.
I also played FFX for about eight hours when I played it the first time. I just honestly couldn't find a decent stopping point until I got to the Djose Highroad.