Resident Evil 1 and Ecco the Dolphin ( the one for PS2 ).
I swim a lot ( living on the beach and such ) and the fear of drowning haunts me so when I play that ADORABLE dolphin and he starts to run out of air I flip out. . . . especially when I was fighting that HUGE freakin' shark in one of the first levels. -pouts- I never did finish the game due to that.

Oh! Yeah!! And Koldelka ( misspell? It's been so long ) for the PS. I think I had like thirty heart attacks playing that game. X_X;