I thought the whole series was pretty clever.

Soulblazer focused on creationism
Illusion of Gaia focused on evolution
Terranigma focused on reincarnation

Enix was the king of innovation on the SNES I tell you. But for such an innovative company, it amazes me they couldn't do anything different with their SNES final bosses beside have big brutes who aren't vulnerable to hits until they're ready to fire beams out their mouths.