It's got to be Family Circus.

At least most of the comics mentioned here (like Cathy, etc.) tend to have some kind of punchline or joke, which the Family Circus does not. It's not even heartwarming, because it usually makes me angry

<a href="http://www.insidejoke.tv/200105/FamilyCircus.asp">This site</a> contains some of the more amazing Family Circus comics.