in ff7 where cloud has to dress as a woman because (SPOILER) you can make him have sex with a large black man in the honeybee inn
and when the short fat man that works for shinRa gets run over (cant remember his name)
in ff8 where if you acquire shiva at the very beginning and name her herpes (or any amusing disease - preferably an STI) Ifrit will say to you when you use her attack "you've got herpes!"

credit to my best mate from school for telling me that one.