That's the beauty of real drafts, huh? Most mock drafts only cover 5x5, anyway, and we have to draft differently because there are many other bases to cover.
If I had the first overall pick, I'd take Vlad Guerrero with no reservations. I'd take a first baseman with my second pick, someone like Todd Helton or Mark Teixeira (if they're available), which is good value at the tail end of the second round. Then I'd probably find a starting pitcher, someone like Roy Oswalt, Jake Peavy or Roger Clemens.