Jay-Z: Hard Knock Life
Outkast: Ms Jackson
Bone Thugs n' Harmony: Crossroads
Tupac: Califnornia Love
Eminem: Lose Yourself
U2: Where The Streets Have No Name
Bonnie McKee: Somebody
Toby Lightman: Devils And Angels
Five For Fighting: Superman
Puff Daddy: I'll Be Missing You
Wayne Wonder: Bounce Along
Mariah Carey: Butterfly/All I Want For Christmas Is You
50 Cent: In Da Club
Alicia Keys: Fallin'
Evanescence: Bring Me To Life
K-Ci and Jojo: All My Life
Usher: You Make Me Wanna
Akon: Locked Up/Lonely
Maroon 5: She Will Be Loved
Alanis Morissette: You Oughta Know
Santana: Smooth/Maria Maria
Destiny's Child: Survivor
Sisqo: Thong Song
Christina Aguilera: Geanie In A Bottle
Will Smith: Gettin' Jiggy Wit It
Next: Too Close
Nelly Furtado: Turn Off The Light
Nelly: Hot In Herre
Vanessa Carlton: A Thousand Miles
Michelle Branch: Breathe
Kylie Minogue: The Loco-Motion
Notorious B.I.G.: Mo Money, Mo Problems
I was tempted to say No Letting Go for Wayne Wonder, but eh. I don't think This Love is M5's signature song, because SWBL was played on the radio long before that gave them the recognition. A few of the songs are covers of older popular songs, but the songs the artists sung made them who they were IMO.
That's all I can think of for R&B/Hip-Hop/Rap artists along with a few other bands.