Omega Weapon attacks in a pattern. If you know when Medigo Flame and Terra Break are coming, the fight becomes very easy even without invincibility items. Also, in case you didn't know, the Defend command will cause Terra Break to inflict 0 damage. Finally, if you're really desperate, I suppose you could always go stat-max with the Devour command.
Once you know what you're doing, Omega's actually really easy to defeat.
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