People who haven't heard of Toejam and Earl make me sad ;__; Go buy a Genesis! Okay, here goes.

A1 - Batman & Robin
A2 - Darkwing Duck & Launchpad McQuack
A3 - Ren & Stimpy
A4 - Mary & Mary's Little Lamb
B1 - Calvin & Hobbes
B2 - Beavis & Butthead
B3 - Roadrunner & Wile E. Coyote
B4 - Chip & Dale
C1 - Sonic & Tails
C2 - Homer & Marge
C3 - Sherlock Holmes & Dr. Watson
C4 - Tweety & Sylvester
D1 - Garfield & Odie
D2 - Peter Pan & Wendy
D3 - Starsky & Hutch
D4 - He-Man & She-Ra
E1 - Squall & Rinoa
E2 - Matt Damon & Ben Affleck
E3 - Tarzan & Jane
E4 - Postman Pat & Jess the Cat
F1 - Superman & Lois Lane
F2 - Mr. Burns & Smithers
F3 - Fighter & Black Mage
F4 - Aragorn & Éowyn
G1 - Toejam & Earl
G2 - Bush & Blair
G3 - French & Saunders
G4 - Kermit & Miss Piggy
H1 - Thelma & Louise
H2 - R2D2 & C3PO
H3 - Frodo & Sam
H4 - Laurel & Hardy