Intelligent Qube, Irritating Stick, Nobody Can Stop Mr. Domino, Donkey Konga... there are quirky games out there, but they're sadly quite rare. Most are content to follow the standard patterns for their genre. I can't really think of ANY quirky games for the PC, not since things like Day Of The Tentacle and Grim Fandango, at least.

Katamari Damacy is quite a wonderful example of successful quirkiness, though. Everyone really does <3 it.