If you like Serious, “mess with your mind” anime, you can’t look past Evangelion, Serial Experiments Lain and Rahxephon. If you like Meche anime, exchange Gundam Wing in there somewhere as well.
If it’s comedy anime you’re after, watch Azumanga Daioh. Seriously, it’s probably the best out there. Otherwise, Love Hina and Excel saga are very good as well.
