It wouldn't be obvious at all, considering that we see no signs of the Cosmo area being a Mako-rich region, nor do we see the Shinra make any effort to construct a reactor in the region.Originally Posted by Light Mage
As for the matter of Red, there's nothing at all to suggest that Mako played a role in the development and evolution of his species. While Mako infusion can be understood to enhance an individual's physical abilities, extreme exposure seems to manifest itself in monstrous and wholly unnatural mutation. For that matter, Red's species doesn't appear to exhibit any obvious "super abilities;" the only salient characteristic is their longevity.