Hojo is perhaps the most evil villain ever. Let's do a checklist:

(*) Experimented on his own child/wife
(*) Killed one of his closest friends
(*) Experimented on the main protagonist
( ) Released the single "Lady in Red"
(*) Attempted to destroy something on a grand scale
(*) Manipulated others to work towards his own personal goals
( ) Destroyed the world
( ) Ate others to absorb their powers

Wow, five stars. Not bad.