I've had this conversation a ton of times with my friends, so basically:
What acadameic subject (Math, History, English, Science, Language?) in school/college/uni are you doing best in? What is your best subject in general?
Example: Biology is my best academic subject, but Chorus and Art (dunno which) are my best subjects.
What's your worst academic subject? What is your worst subject in general?
Like I said, Biology is my best academic subject, I think I have a 96 average in it, and Chorus and Art are my best subjects. My worst subject, but generally and academically, is Math. I hate Math, I just don't get it. I'm great at Art/Music/English/History and I'm even good at Science, which is a more mathematical type of thing, but Math is just... hard. xD