I like .hack//SIGN, Futurama, Family Guy, Tsubasa Chronicle, Fullmetal Alchemist, Harvey Birdman Attorny at Law and some others. I do like X but I just got done watching that so I don't want to say anything yet having just come off the hype of it.

There are plenty of more adult oriented cartoons now but they are all still comedy based. That is the huge difference. I have not ever seen a whole lot of true comedy based anime. I have faith that Bobobo Bo Bo Bobo can come through but if anime has taught me anything it will get way too serious at the end and smurf it up.