(SPOILER) Yeah there are a few. I'm not sure if you want me to list them or not, so I'll put them in a different box. The returning Towns and Dungeons are in the next spoiler box.

Start of List
(SPOILER)Dungeons:
-Castle Dipan/Lost City of Dipan
-The Forest of Spirits
-Palace of the Dragon
-Tower of Lezard Valeth
-Seraphic Gate

Towns:
-Coriander
-Crell Monferaigne
-Villnore
-Solde (Kind of. It was a dungeon, Solde Catacombs in the original)
-Dipan

I don't think I missed any, but I'm going from memory so it's possible.

End of List

(SPOILER)
And nope, no Bloodbane.