Quote Originally Posted by Omni Legacy
Vs. Mewtwo from Pokémon R/B
You have to admit that the first time you went up against Mewtwo it was epic. Boss fights in Pokémon are difficult for the main reason that they CAN NOT be defeated or the purpose is lost, but they must be weaken. In this case EXTREAMLY weakened. To make it worse, he had a defense ability (Barrier) and a restoritive ability (Recover). This was a battle of luck. You can hope he gets froven with Ice Beam and just wittle his HP down or you can put him to sleep and pray he doesn't wake up. Or you could throw a Master Ball at him. Eather strategy works.
I forgot about Mewtwo. I'm pretty sure most people just used a master ball.