Probably the main thing that turns me off of most RPG's is the turn-based combat. Maybe it's because I'm more into FPS's and Action/Adventure titles, but I often feel bored and sometimes like I don't have enough control in the turn-based style. I'm more partial to the system used by the Tales series, especially Tales of Symphonia. Also, I wouldn't mind a setting that wasn't medieval. Don't get me wrong, I like fantasy, but there are so many other options that could work as opposed to the standard fare.