Not usually. I did make a few nasty comments towards my Metroid Prime game recently though. I was doing some sequence breaking, and had gotten to the Omega Pirate without the X-Ray Visor or the Gravity Suit, only to learn that he can't be killed without the X-Ray Visor. Even if you aim the weapons directly at his weak point, they won't do damage if you can't see him. That pissed me off a bit...