I have a wireless mouse and I love it. So phooey on y'all.

How does the mouse connect to the computer? Usually there's a transmitter/reciever plugged into the mouse/USB port on your computer. Check that and make sure it's plugged in. Have you installed anything new that might have affected your mouse drivers? Go to your Control Panel (assuming you're running Windows) and go to the System contol panel. Under the Hardware tab go to the Device Manager. Expand the Mice and other pointing devices section and see if your mouse shows up with a yellow exclamation point. If it does it means something is wrong with it. You can always click on it anyway and try to troubleshoot it from there.