A high rune, maybe two (but don;t count on it), since it can be used for Eternity, Death, Destruction, and the most important of them all, Grief. Also remember to keep Berserker Axes, the Elite version of normal one handed Axes. These are the highest power weapons in the game when combined with a good runeword. An Os'd Berserker Axe is worth 2+ high runes (not the Set item, the white item).