Hmm...the villains I can think of at the moment would be...

*The Prime Minister from 'V for Vendetta'
*That woman from 'Misery' (who kidnaps the author) - the things she did was sick!
*Agent Smith from 'The Matrix' Trilogy
*Jigsaw from 'Saw' - he makes me cringe...

They are the most...well ruthless of villains I can think of. But if anyone watches Bollywood films you'll find there's loads of villains that are even worse.