Well a little tired and sleepy, but from memory:

AVG free kinda recently got a version change, and may be a little more potent now. Though its been a long time since i've encountered a true virus to test it on. More frequently I run into vundo/smitfraud.. which require third party cleaners.

Typically it seems my friends/family are infected with spyware rather than viruses these days.

Adaware SE from lavasoft and the VX2 add on cleaner i believe its called.

AVG Antispyware(30 day trial i believe still, used to be Ewido, but was bought out)

AVG Free

If none of those crack what you've got, I'd research some antispyware forums like spywareinfo, and ask them for help. There are many small third-party programs in development to target and combat specific stronger malware that the big suite programs have trouble removing.

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Do you have any errors or information on the malware? symptoms.. etc.

Smitfraud is renowned for imitating Windows update and downloading Fraudlent antispware programs that it wants you to buy.