[q=Nominus Experse]To really get rid of everything that is on your computer, I would advise downloading a program called HiJackThis.

Once you have such a program, head on over to a specialized forum that deals with malware and the like, such as Techguysupport or some such place. Sometimes you will need to download several programs, but in a time period of two or so days, you'll be rid of EVERYTHING malicious on your computer.[/q]

HijackThis! is effective if used correctly. The problem is that it's a lot more difficult to use, and a lot more dangerous if you don't know what you're doing. I recommend using it if nothing else you try gets rid of whatever mal/spy/adware or virus you have.

Really, all anyone should need to be pretty safe is Ad Aware and an antivirus. Preferably one that's under GPL, like ClamAV.

But realistically, if you're not cool with virii, install Linux.