Okay first of all topic isn't supposed to address the fact that SE said they aren't making it and aren't interested in it, it is simply about personal opinion on another sequel.
Before I got to know about the 2.5 novel and - will - I would have of course said no way, but now that the story is absolutely opened again I personally feel that it does need a definite ending even though I can't really see just how it's possible to save this.
Also if you are for sequel, what form would you want? Another game? Another novel? Or perhaps long movie that would wrap it all up in 2 hours and be done with it?
Personally if it was my choice, I would say movie probably could still somehow save the story in reasonable way without making us actually play countless hours through well known world in well known danger of Sin.