I'd say there are a lot of things we'll have to find our way through yet - technology wise and culture wise, too.

1) Energy. That whole cold fusion power type thing will be immense.

2) Jobs. There will come a time that doesn't look too far off where jobs will begin to fall away. There are more and more people in the world and companies are constantly finding new ways for one person to do the same job as two did beforehand. Once computers do start taking over more people's jobs - and they certainly will - I do wonder how long it will take before currency comes into question. Who will provide income for families? Will food be free? etc. etc. etc. There's just so much to go into here. x_x

3) Space travel. I sadly don't imagine it will happen in my lifetime, but I long for the day that manned space travel to other planets finally happens, and people begin to colonise other planets. This is probably the one thing that I feel will change everything, forever. If people ever get to the stage that they can fly from planet to planet in what feels like months, then we are certainly well beyond what I could ever hope to see. It almost makes me sad that I won't get to see such a thing happen.

All this flying car business? Yeah, that's not technology that is out of reach. That's already here, guys. It's just not a sensible or efficient mechanism in today's world as of yet. I think people will still be travelling in cars despite being able to fly for quite some time.

As for Artificial Intelligence, it's there already, too. I assume what you mean is just an advanced version of this - a 'thinking' robot, which makes it's own rules and it's own decisions. If we ever get to this, well, we're certainly getting to the point where one must consider the "I, Robot" and "Terminator" deals - but eh, I won't bother considering putting much thought into that until we're a lot closer to the time.