Oh it's wonderful. It's annoying to reach away from the keyboard even if it's just to a touchpad (this is exacerbated if the laptop is in my lap).

When I have the exquisite opportunity to use Microsoft Office 2007, I find that since it's freaking weird that I do most of the basic actions by long-remembered keyboard shortcuts and flail when I have to do something that I don't know a shortcut for (center and merge anyone?).

mice and pointing devices are handy for pages with a million links. I get tired of holding down tab pretty quickly xD

Now for the converse; how well could you guys survive sans keyboard?