Best Film: Avatar - because it's made a ton of money
Best Director: James Cameron or Kathryn Bigelow - see above, or the Academy will want to make history
Best Actor: Jeff Bridges - because he's lost so many times before
Best Actress: Sandra Bullock - because the Academy loves those 'ballsy' roles, and because the shortlist is pretty poor
Best Supporting Actor: Christoph Waltz - he's won every other award so far
Best Supporting Actress: Monique - ditto

Otherwise expect Up in the Air to scoop Best Adapted Screenplay, Up to win Best Animated Film, and the ceremony to last an eternity.