@loony bob
Not as deep menus, and at least not for commonly used actions. Snappier confirmation window popups. If you're gonna ask me if i'm sure about something, at least make the question box pop up instantly.

Better targeting mechanics. Sure, you could "get used to it" and it won't be "as much" of an issue. I find this to be a poor excuse for not designing it better.

Drag-and-drop for menu items, like when you want to set skills, move/trade/sell/buy items.

Automatically remember the skillsets of your previous job. If I set up a nice hotkey bar on pugilist, then change to marauder, and then back to pugilist, it seems like which skills are automatically hotbared are a random mix of some of the marauder skills i set, and some of the pugilist skills i had before i changed to marauder.

I don't particularly care if a more mouse-friendly UI wouldn't work well on a console. They can't expect to have *one* bastard-UI that tries to be good for both gamepad and KB+mouse. If they want to make it good for both control schemes, they will need to design two separate UIs. One made specifically for kb+mouse, and one for gamepads.

I could bring up several more points, but someone's yelling at me to come to bed. Good night!