So this was a pretty lively thread on SomethingAwful so I thought I'd steal the idea and see what responses people here have.
Which women in gaming are actually good characters ie. not brainless beauties in need of saving or some skankified "badass"?
I realize it's probably not the most obvious choice considering the series but I really don't like The Boss. So I'm gonna say another MGS female.
Olga Gurlukovich - Metal Gear Solid 2
A skilled soldier with a very deep connection to her war buddies. Nevertheless, she was forced into a most unenviable position - to sacrifice one family for her actual family. She did everything for her baby and when it came time to make the ultimate sacrifice, she lamented what she had done and made no excuses.
She was really just one of the strongest and most respectable characters in the series.