Anyone tried a Single Stat run? You pick a stat (or even better, random number generate one!), and ONLY put points into that one stat. Added fun is to make it so that every Soul you make MUST be spent on that stat.

So, you end up with Vitality juggernauts who can't hit for trout but can take obscene amounts of damage, or a Strength glass tank, dealing obscene amounts of damage but getting killed by the most delicate of a Gargoyle's farts. It sounds pretty decent.