I've honestly had to debate this question cause as much as I complain, I don't hold that much animosity towards any particular series or genre. If I had to kill franchises it's for personal reasons...

Metal Gear Solid - I really love the series, MGS3 is easily one of my favorite games of all time and Peace Walker is brilliant, but the series needs to die. Not because the series is in a downhill spiral, but because I would like the series to retire on a high note before Kojima spends the next 15 years churning out sequels for it and becomes bitter about the industry like Kenji Inafune and reading some of his interviews, he sounds like he's heading in that direction. Not to mention that even Kojima is going to start running out of ideas eventually and the series will begin to get weaker and dumber. I'd rather see it end on a high note. It helps that there really isn't anything left to talk about for the series unless MGS5 is going to be a prequel about the Boss (which would actually be really cool) or Kojima retcons MGS4's ending for Snake and revitalizes him with nanomachines so he can start a new story arc, but that idea just sounds terrible. The point is that Snake's story has run its course and it's time to let him rest before he becomes Konami's version of Mario or worse, Capcom's version of Mega Man. Speaking of which...

Resident Evil - seriously, you need to drop Umbrella Corp and come up with some new way to create zombie apocalypse, I mean how many zombie apocalypses can one evil megacorp cause before the U.N. is going to step in have them exterminated? Even Shin-Ra doesn't have as good of PR as UC does. You really should have taken the opportunity that RE4 gave you and give the series a fresh start instead of dragging everyone back into the bulltrout of the previous games. So RE7 better not have UC or any of it's affiliates or you should lay the series to rest.

Silent Hill - Same issue, you need to get rid of The Order and stop torturing Alessa/Cheryl/Heather Mason cause how many times can you retell the plot of SH1? You should have taken a clue from SH2 and instead focused character dramas facing their real life demons in a spooky town called Silent Hill rather than later entries that always make everything tie back into the cult from the first game. Just be rid of them and their plot to resurrect their doomsday cult god and let's all move on with our lives, I'm sure if you put your heads together you can make something just as scary without the backlog of convulated nonsense. Though SH: Homecoming was a nice twist on the cult.

Fabula Nova Crystallis - Here's what you need to do Squenix, cancel Lightning Returns and just make some bulltrout DLC ending for XIII-2 starring Lightning or just don't. Tell everyone in your in-house development to stop what they are doing and put their projects on hold. Pull them all together and make them finish Versus XIII by holiday season of next year (I'm trying to be realistic) after 6 years of development there cannot possibly be any kind of new idea that should be introduced into this game by this stage of development. If you have to lock Nomura into a closet cause he can't stop being an "artist" about every little detail of the game then so be it. I would like to see this game before my hypothetical children have their own hypothetical demon spawn children. I don't care if it has to be rushed and unfinished, it's never stopped you before and if it was going to be any good, I figure six years is more than enough time to show the "meat and potatoes" of the grand design. We as fans are big enough to forgive a lack of polish if the core of the game is good, I mean that was practically every game you made in the PS1 generation.

After this is done, decide if you are going to translate Type-0, then put it to rest. Don't bother waiting for the Vita to get popular, cause it's a few years worth of games away from having an exceptionable gaming library and it needs a price drop before average consumers are going to pay attention. We all have PSPs, just translate that version and be done with it. Once that is done, kill FNC and let us all agree to never speak of this Compilation experiment again. Just make Nomura start working on KH3, and get everyone else back on current projects and FFXV. Thank you.