In Guild Wars 2, I'd sacrifice a little bit of stats for better fashion all the time. That's also a game where your skills and game knowledge always goes a lot further than a few points on the character sheet, so it was worth it. The dying system is pretty fantastic as well, so fashionistas have a lot going for them in that game.

In the Elder Scrolls I tend to go around without a helmet pretty frequently, but when it comes to hardcore spelunking, I gotta completely suit up for that.