I think a few skills are required:

* Resource management - wandering around is dangerous, can you survive long enough to find the place you need to go and get back again alive?
* Memory - Have I been here before? Have I explored all 5 of these side-paths? Where did that guy say I was supposed to go again?
* Patience/perseverance - Can you stick with the game long enough to make it through? Especially when you keep getting killed by stupid random encounters while you're trying to accomplish things.

Not gonna lie, I came close to giving up a bunch of times out of frustration. Particularly because of this quest: (SPOILER)"Find the military base", where you have to progress by talking to some completely random no-name guy in a bar . This game does take things to an extreme.

I do recall a few places on the map where people would say "X is south, Y is north", but yeah, not a lot of those.