A1.4 - Roadrunner & Wile E. Coyote
A2.3 - Pinky & Brain
B1.4 - James Bond & Bond Girl
B2.3 - R2D2 & C3PO
C1.4 - Neo & Agent Smith
C2.3 - Mulder & Scully
D1.4 - Frodo & Sam
D2.3 - Mr. Burns & Smithers
E1.4 - Homer & Marge
E2.3 - Rocky & Bullwinkle
F1.4 - Beavis & Butthead (come on these perverted maniacs losing against muppets? they don't say stuff as good as these!)
F2.3 - Bart & Lisa
G1.4 - Itchy & Scratchy
G2.3 - Mario & Luigi
H1.4 - Batman & Robin
H2.3 - Calvin & Hobbes