I remember a short-lived but amusing '90s sitcom called Shasta, wherein the main character bragged about having both a PlayStation and an N64 - thus allowing him to play Metal Gear Solid or Turok 2 - or both.

Spaced, a UK comedy starring the mighty Simon Pegg, used video games to great effect to illustrate the characters' moods. Tim has a bad experience with a girl, so he starts Tomb Raider III so he can drown Lara repeatedly. A Tekken 3 fight between Paul and Nina is used to punctuate verbal sparring between the hero and heroine. Stuff like that.