hmmm here goes in no order:

Final Fantasy VIII
Vagrant Story
Front Mission 3
Breath of Fire 4
Mass Effect (series, hard to pick one game out of the 3 since they all rely on one another)

I know everyone will bitch about FFVIII (well maybe Locky will agree with me but thats about it) but since it was the RPG what first got me really in to RPG gaming I feel it deserves it's mention on there, plus without VIII I would never have first joined EoFF and met you fine rubes. Plus Triple Triad is amazing.

Honorable mentions:

Remaining FF games
Fallout series (including tactics and 3, though I'm yet to play NV)
Baldurs Gate 2
Never Winter Nights
Diablo 2
Dragon Age Origins
Deus Ex

There's probably some I've forgotten to mention.