I don't know about the cards in comparison to each other, but do know most higher end software usually has nVidia in mind. Then they generally have to tone it down for ATI. PS2 emulators are designed for nVidia, and then later tweaked for AMD. The recent Wasteland 2 was designed for nVidia (AMD has overheating issues while playing the game). Just a few instances I've come across recently. But I'm no guru.