It's not really much of a factor since you literally have to go out of your way to make the most of it, but the real isue here is why bother when you're going to be spending the end game spamming Thievery/Dragon's Crescent/Shock/Frog Drop which all have either grossly overpowered damage algorithms that can easily be exploited without min/max. Just play the the game and have fun without sweating all the minor details.