The final scene in MGS3 at The Boss' grave after you learn the truth.

The revelations about Fei Fong Wong in Xenogears. The destruction of Solaris, Id's first physical appearance.

The deaths of Psycho Mantis, Sniper Wolf, Vulcan Raven, and the Cyborg Ninja.

The ending to Ico

The first time your main character uses the Evoker and the entire final part of Persona 3, Starting in January and concluding to the very end of the game.

The Opera scene from FFVI

Crono's death and rebirth

Just to name a few...